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HPV vaccine not associated with chronic fatigue or other autonomic dysfunction syndromes
Clinical Question
Is the human papillomavirus vaccine associated with the development of autonomic dysfunction?
Bottom line
The loosely categorized autonomic dysfunction syndromes include chronic fatigue, complex regional pain syndrome, and postural orthostatic tachycardia syndrome. Administration of the human papillomavirus (HPV) vaccine is not associated with an increase risk of developing any of these syndromes. 4
Reference
Study design: Case series
Funding: Industry + foundation
Setting: Population-based
Synopsis
The study population — 869 women with syndromes of autonomic dysfunction (136 with chronic fatigue syndrome, 535 with complex regional pain syndrome, and 198 with postural orthostatic tachycardia syndrome) — was drawn from the Danish nationwide population database. The women were identified for up to 9 years following the introduction of HPV vaccination in 2006. A total of 433 individuals (49.8%) with autonomic dysfunction had received at least one vaccination. However, HPV vaccination did not statistically significantly increase the rate of a composite outcome of developing any of the syndromes over the subsequent 365 days. Also, it was not associated with an increased rate of any individual syndrome.
Reviewer
Allen F. Shaughnessy, PharmD, MMedEd
Professor of Family Medicine
Tufts University
Boston, MA
Comments
vaccinations
Those that don't accept vaccinations won't believe this paper, and those that accept vaccinations- physicians et al- will believe.
HPV vaccine and potential Neuro defects.
This is reassuring and fits with all the other myths of the dangers of vaccination.
I have five Granddaughters so it is of special interest to me, apart from for my patients!