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Influenza (H1N1) vaccination during pregnancy not associated with autism
Question clinique
Is influenza vaccination during pregnancy associated with autism?
L’Essentiel
No. At least not the A(H1N1)pdm09 ("swine flu") vaccine. In Sweden. Over the subsequent 6.7 years. In almost 40,000 exposed infants as compared with more than 29,000 unexposed infants. Even when given in the first trimester. 1b
Référence
Plan de l'etude: Cohort (prospective)
Financement: Government
Cadre: Population-based
Sommaire
This study was conducted on infants who were in utero during the 2009 influenza pandemic in which the A(H1N1)pdm09 ("swine flu") vaccine was offered at no charge to all pregnant women (and others) in Sweden. Using the national birth registry, the researchers identified 39,726 infants exposed to the vaccine, including 13,845 in the first semester. They also followed 29,293 infants of mothers who didn't receive the vaccine. During a mean follow-up of 6.7 years, 394 (1.0%) of exposed children and 330 (1.1%) of unexposed children had a diagnosis of autism spectrum disorder. Prenatal exposure to the vaccine was not associated with a later diagnosis of either autism spectrum disorder or autistic disorder, even when looking just at children exposed in the first trimester. This was not a randomized study and it was performed during a single influenza season with a single vaccine.
Reviewer
Allen F. Shaughnessy, PharmD, MMedEd
Professor of Family Medicine
Tufts University
Boston, MA
Commentaires
Good POEM
Good POEM
Valuable information for prenatal patients
An important topic as there is sometimes prominent misinformation re: vaccines
Vaccine and autism
Will this conspiracy never die?