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Indice de pertinence clinique de l’information
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Décembre  
30 Gabapentin is equal to placebo for pain relief in women with chronic pelvic pain (GaPP2), but with more side effects 43 % (n=1261)
29 No increased risk of spinal hematoma with lumbar puncture in adults with coagulopathy 31 % (n=1134)
27 COVID-19 research briefs: Symptoms persist for at least 60 days for one-third of hospitalized patients 53 % (n=1242)
24 Human papillomavirus vaccine, especially before age 17, is associated with a large reduction in invasive cervical cancer 64 % (n=1241)
23 Empagliflozin reduces hospitalizations for heart failure in patients with HF and a left ventricular ejection fraction < 30% 50 % (n=1115)
22 Low-dose CT screening of smokers decreases lung cancer deaths, but not overall mortality 52 % (n=1148)
21 Low-dose edoxaban effective for stroke prevention for elderly patients with atrial fibrillation 45 % (n=1146)
20 COVID-19 research briefs: Small randomized trial finds some benefit with fluvoxamine treatment 33 % (n=1188)
19 COVID-19 research briefs: Updated age-specific mortality patterns related to SARS-CoV-2 infection. 57 % (n=1182)
18 Biofeedback does not add benefit to structured training for stress or mixed urinary incontinence in women 36 % (n=1059)
17 Coenzyme Q10 not helpful for statin-associated muscle symptoms 50 % (n=1205)
16 Giant cell (temporal) arteritis: No laboratory test or physical finding is pathognomic 51 % (n=1252)
15 Uncertain benefit of electroacupuncture for chronic low back pain 42 % (n=1056)
14 In high-risk older patients with atrial fibrillation, rhythm control reduces cardiovascular death and stroke, but at a price 53 % (n=1173)
13 COVID-19 research briefs: Frontline health-care workers and their families are at an increased risk of hospitalization 57 % (n=1216)
12 COVID-19 research briefs: Case fatality ratio due to COVID-19 appears to be declining 51 % (n=1179)
11 Group training for stress or mixed urinary incontinence in women is as effective as one-on-one training 42 % (n=1099)
10 No difference in overcorrection risk with rapid bolus vs slow infusion of hypertonic saline for severe hyponatremia (SALSA) 29 % (n=1092)
09 Limited data on probiotics for treating patients with celiac disease 42 % (n=1117)
08 Musculoskeletal surgery for nontraumatic pain: not a great analgesic 56 % (n=1152)
07 Quality of life no different after antibiotics vs surgery for appendicitis, but 30% still require surgery in 90 days 41 % (n=1164)
04 Modelling study shows less-intense screening is okay for men with low baseline PSA levels 53 % (n=1103)
03 Dapagliflozin reduces mortality and renal replacement in patients with chronic kidney disease 55 % (n=1146)
02 Influenza (H1N1) vaccination during pregnancy not associated with autism 56 % (n=1251)
01 No proven benefit of universal ultrasound screening for fetal macrosomia 26 % (n=1102)
Novembre  
30 Modest increase in rate of completed miscarriage with mifepristone before misoprostol 30 % (n=1005)
29 COVID-19 research briefs: Another study assessing excess mortality in the United States attributed to the pandemic 33 % (n=1127)
28 COVID-19 research briefs: Evidence for effectiveness for tocilizumab for COVID-19 treatment inconclusive and not encouraging 28 % (n=1098)
27 Small study finds recurrent spontaneous coronary artery dissection risk not associated with subsequent pregnancy 17 % (n=1037)
26 Low-dose zinc (5 mg or 10 mg) is as good as 20 mg for childhood diarrhea 24 % (n=1100)
25 Three strategies are effective in managing patients with medication overuse headaches 47 % (n=1052)
24 Intensive lifestyle therapy for weight loss was successful in a low-income, underserved population 45 % (n=1163)
23 Nocturnal oxygen for COPD patients who do not qualify for daytime oxygen is unlikely to be helpful (INOX) 37 % (n=1152)
22 COVID-19 research briefs: COVID-19 responsible for excess mortality in the United States in 2020 37 % (n=1215)
21 COVID-19 research briefs: Symptoms of COVID-19 persist for at least 60 days in 67% of patients 57 % (n=1266)
20 No improvement in re-bleeding rate with earlier colonoscopy for patients hospitalized with lower gastrointestinal bleed 33 % (n=1156)
19 Fecal calprotectin is reasonably accurate in identifying kids with inflammatory bowel disease in primary care 39 % (n=1130)
18 No preference for outpatient rehabilitation program after total knee arthroplasty 40 % (n=1114)
17 Whether a viral or bacterial pathogen is detected has little effect on cough symptoms or duration 62 % (n=1213)
16 Point-of-care ultrasound is useful for ruling out skin and soft tissue abscess 38 % (n=1213)
15 COVID-19 research briefs: Tests for diagnosing SARS-CoV-2 lack sensitivity 57 % (n=1133)
14 COVID-19 research briefs: Development of a mortality score for hospitalized patients 28 % (n=1109)
13 Better primary care continuity is associated with lower mortality risk 71 % (n=1197)
12 The balance of benefits and harms no longer favors aspirin for primary prevention 71 % (n=1322)
11 Plaster cast and walking boot, each with rehabilitation, are comparable in patients with acute Achilles tendon rupture 36 % (n=1224)
10 Vitamin D does not reduce the incidence nor the recurrence of depression in adults 51 % (n=1271)
09 HPV vaccine not associated with chronic fatigue or other autonomic dysfunction syndromes 50 % (n=1222)
06 Pay attention to gut feelings about cancer in patients 57 % (n=1256)
05 Acute cardiovascular events are common in patients hospitalized with influenza 51 % (n=1207)
04 Genotype-guided selection of oral P2Y12 inhibitor therapy no better than standard therapy after PCI for ACS or stable CAD 23 % (n=1029)
03 Valaciclovir decreases the frequency of vertical transmission among pregnant women with primary cytomegalovirus infection 18 % (n=1116)
02 BMD testing: one and done 64 % (n=1330)
Octobre  
31 COVID-19 research briefs: Hydrocortisone may reduce the need for organ support interventions in critically ill patients 29 % (n=1170)
30 Vitamin D not effective for reducing asthma exacerbations in children with asthma and low vitamin D levels (VDKA) 36 % (n=1139)
29 Breast implant–associated lymphoma incidence highest with textured implants (1 in 871 implants) 26 % (n=1155)
28 USPSTF 2020 recommends counseling for sexually active adolescents and at-risk adults to prevent STIs (B recommendation) 60 % (n=1144)
27 Oral progestogen increases live birth rate among women with threatened miscarriage 28 % (n=1167)
26 Direct oral anticoagulants (DOACs) plus clarithromycin associated with higher risk of bleed than DOACs plus azithromycin 56 % (n=1236)
25 COVID-19 research briefs: Using public transportation or socializing in food/beverage outlets increases rates of infection 63 % (n=1202)
24 COVID-19 research briefs: Pregnant women may manifest fewer symptoms, but may need more intensive treatment if symptomatic 36 % (n=1150)
23 Hyponatremia predicts poor outcomes in patients hospitalized with acute sickle cell crisis 15 % (n=1061)
22 Messages of fear and empowerment are best for reducing inappropriate antibiotic use 68 % (n=1195)
21 Nirsevimab in a single intramuscular dose prevents medically attended RSV infection and hospitalization in preterm infants 17 % (n=1047)
20 Risk of atypical femoral fracture higher with longer duration of bisphosphonate use and in other groups of women 57 % (n=1194)
19 Compression reduces recurrent cellulitis in patients with chronic leg edema 64 % (n=1268)
18 COVID-19 research briefs: High incidence of thrombotic events in patients hospitalized with COVID-19 35 % (n=1260)
17 COVID-19 research briefs: Not all face coverings offer similar degrees of protection 73 % (n=1288)
16 American Gastroenterological Association practice guidelines for the use of probiotics 45 % (n=1179)
15 Bedroom air filter does not affect pollen allergy symptoms 42 % (n=1151)
14 Mindfulness classes may lead to a reduction in headache frequency 50 % (n=1135)
13 Bariatric surgery associated with decreased all-cause mortality and lower rates of other obesity-related events 50 % (n=1174)
12 Serum procalcitonin not very accurate in diagnosing children with pneumonia 26 % (n=1074)
09 Initial cast immobilization is a reasonable option in persons with scaphoid fractures 44 % (n=1164)
08 Use of the Cytosponge to screen for Barrett's esophagus is feasible in primary care settings 30 % (n=1087)
07 Magnesium sulfate reduces the risk of cerebral palsy in offspring when given to women prior to preterm birth 21 % (n=1115)
06 Baloxavir is effective for influenza prophylaxis in household contacts 36 % (n=1080)
05 For patients with chronic kidney disease, prehydration prior to contrast-enhanced computed tomography is unnecessary 42 % (n=1171)
04 COVID-19 research briefs: rapid control of outbreak in Beijing; antibodies estimate infection fatality ratio in Iceland 45 % (n=1146)
03 COVID-19 research briefs: BMJ living systematic review of drugs for treatment; 5 days equivalent to 10 days of remdesivir 32 % (n=1082)
02 Rifabutin added to combination therapy might be a new option for treating H. pylori infection 44 % (n=1090)
01 No clear benefit to daily probiotics for reducing antibiotic use among elderly care home residents 38 % (n=1131)
Septembre  
30 Progression of papillary thyroid cancer is lower in older adults 34 % (n=1110)
29 Negative colonoscopy result predicts no colon cancer for more than 10 years 63 % (n=1291)
28 Consider screening adolescent and adult women at least once for anxiety 50 % (n=1087)
25 Algorithms based on high-sensitivity troponin quickly and accurately rule out acute myocardial infarction 45 % (n=1130)
24 American Thoracic Society guideline for initiating medications for smoking cessation 66 % (n=1140)
23 SR: BRCA mutations are not associated with colorectal cancer 38 % (n=1170)
22 Platelet-rich plasma injections = placebo in patients with nonsurgically treated acute Achilles tendon ruptures 29 % (n=1158)
21 Schmutz in the urine contaminates culture results 61 % (n=1156)
18 Limited data on inhaled steroids for preventing acute mountain sickness 17 % (n=1079)
17 Expulsion rates of intrauterine devices placed postpartum vary based on several factors 37 % (n=1121)
16 Mode of delivery unchanged with delayed or immediate pushing in second stage labor with epidural analgesia 21 % (n=1048)
15 Chest x-rays, electrocardiograms, and Pap tests in low-risk patients are associated with further tests and procedures 64 % (n=1220)
14 Minesapride = placebo to reduce constipation in patients with irritable bowel syndrome with predominant constipation 36 % (n=1073)
11 Vibegron effective versus placebo but not tolterodine for adults with overactive bladder symptoms (EMPOWUR) 39 % (n=985)
10 Fewer subsequent strokes with ticagrelor plus aspirin than with aspirin alone 46 % (n=1101)
09 After community lung cancer screening, rates of follow-up imaging are lower but the rates of some procedures are higher 36 % (n=1019)
08 Clascoterone 1% is effective for moderately severe acne (number needed to treat = 7 - 11) 38 % (n=1056)
07 20-year follow-up of WHI trials: lower breast cancer mortality with CEE alone, no difference with CEE plus progesterone 52 % (n=1201)
04 Early initiation of RRT in critically ill patients with AKI does not lower 90-day mortality 19 % (n=1031)
03 Thyroid replacement = placebo for symptom resolution in subclinical hypothyroidism 60 % (n=1222)
02 Small changes in laboratory processing doubles diagnoses of gestational diabetes 37 % (n=1098)
01 Listen for clues that indicate which patients who are taking opioids may be open to other options 57 % (n=1107)
Août  
31 Treatment of acute hypoxemic respiratory failure with noninvasive ventilation using a helmet or face mask led to fewer deaths 25 % (n=1115)
29 COVID-19 research briefs: Physical distancing measures are effective for reducing spread; colchicine may reduce symptoms 58 % (n=1158)
28 Short-term low back pain relief with placebo 53 % (n=1132)
27 Long-term outcomes improved with shorter door-to-needle times for stroke patients who receive thrombolysis 41 % (n=1101)
26 LNG-IUD more beneficial than systemic progestin to treat complex atypical endometrial hyperplasia in obese women 30 % (n=1065)
25 American College of Rheumatology guideline for managing patients with gout 68 % (n=1140)
24 Long-term follow-up of CAPP2: aspirin prevents colorectal cancer in Lynch syndrome carriers 25 % (n=1075)
23 COVID-19 research briefs: Persistent fatigue, dyspnea common following hospitalization; promising vaccine developed in China 51 % (n=1106)
22 COVID-19 research briefs: Promising preliminary data on COVID-19 vaccines from the United States and United Kingdom 60 % (n=1059)
21 Yoga enhances conventional medical therapy in patients with episodic migraine 43 % (n=1108)
20 Buffering lidocaine 1%/epinephrine with sodium bicarbonate in a 3:1 ratio is as effective and less painful than a 9:1 ratio 43 % (n=1078)
19 PPI use associated with a small increased fracture risk in children 35 % (n=1147)
18 Three days of amoxicillin is effective for pneumonia with tachypnea in young children 37 % (n=1119)
17 LABA+LAMA+ICS associated with greater decline in all-cause mortality than LABA+LAMA in patients with severe COPD (IMPACT) 63 % (n=1054)
16 COVID-19 research briefs: Antibody testing yields variable results; population study provides rich data on infection rates 49 % (n=1136)
15 COVID-19 research briefs: Personal protective equipment prevents transmission of COVID-19 in Chinese healthcare workers 65 % (n=1196)
14 USPSTF 2020 recommends screening for unhealthy drug use in adults by asking questions (B recommendation) 55 % (n=1065)
13 Givosiran effective for acute intermittent porphyria (ENVISION) 11 % (n=934)
12 Triple inhaled therapy provides a small reduction in moderate exacerbations, no effect on severe exacerbations (ETHOS) 57 % (n=1067)
11 Tinnitus guidelines from the United Kingdom's National Institute for Health and Care Excellence (NICE) 55 % (n=1094)
10 Compression stockings unnecessary for inpatients who undergo elective surgery 36 % (n=1132)
07 Probiotic formulation prevents microbiologic recurrence of bacterial vaginosis; no information about effect on symptoms 45 % (n=1138)
06 Biomechanical footwear may be effective for reducing pain in adults with knee degenerative joint disease 51 % (n=1103)
05 Intra-articular hypertonic dextrose injections marginally improve pain and function in patients with knee osteoarthritis 38 % (n=1105)
04 The American Thoracic Society guideline for managing patients with chronic obstructive pulmonary disease 64 % (n=1098)
03 Physical therapy better than steroid injections for knee osteoarthritis after 1 year 64 % (n=1105)
Juillet  
31 Antenatal corticosteroid exposure associated with mental and behavioral disorders 100 % (n=1)
30 Catheter-based renal denervation slightly decreases blood pressure without medications 48 % (n=6)
29 Little if any benefit to early invasive strategy for stable angina and at least moderate reversible ischemia (ISCHEMIA trial) 48 % (n=6)
28 Easy rule identifies patients with low-risk penicillin allergies 70 % (n=34)
27 Nondrug therapy provides modest short-term improvement in fatigue in older adults 48 % (n=6)
26 COVID-19 research briefs: Updated recommendations on diabetes management during Ramadan and pandemic 57 % (n=5)
25 COVID-19 research briefs: ACEIs and ARBs not associated with COVID-19 or the severity of the disease 44 % (n=7)
24 No mortality difference between early and delayed initiation of renal replacement therapy in critically ill patients with AKI 17 % (n=10)
23 Canadian Syncope Risk Score effectively rules out the risk of serious outcomes after syncope 57 % (n=7)
22 Some drugs slightly improve cognition in people with dementia; effects on behavioral or psychological symptoms remain unclear 57 % (n=7)
21 USPSTF 2020: insufficient evidence to recommend counseling to prevent illicit drug use in kids and young adults (I statement) 43 % (n=7)
20 Pulmonary rehabilitation after hospitalization for chronic obstructive pulmonary disease improves mortality 50 % (n=6)
19 COVID-19 research briefs: convalescent plasma marginally improved COVID-19 outcomes in severely ill patients in China 38 % (n=4)
18 COVID-19 research briefs: COVID-19 mortality in currently treated cancer patients not higher than in other cancer patients 86 % (n=4)
17 Apixaban is noninferior to dalteparin for venous thromboembolism associated with cancer 48 % (n=9)
16 Rivaroxaban reduces acute limb ischemia, but increases major bleeds after revascularization for PAD (VOYAGER PAD) 57 % (n=5)
15 Vericiguat for heart failure reduces hospitalization, but not mortality 44 % (n=6)
14 Fecal occult blood testing is inaccurate as part of diagnostic workup 44 % (n=6)
13 Perioperative probiotics and synbiotics reduce postop infections in adults who undergo elective abdominal surgery 50 % (n=6)
12 COVID-19 research briefs: self-collected swabs accurate for detection; fever, cough, elevated CRP common in COVID-19 32 % (n=5)
11 COVID-19 research briefs: Corticosteroids reduce mortality in patients on oxygen; postexposure hydroxychloroquine ineffective 35 % (n=1197)
10 New clinical prediction rule (the Pediatric Appendicitis Laboratory Score) accurately rules out appendicitis in children 35 % (n=1232)
09 Unrecognized myocardial infarction carries similar prognosis to recognized myocardial infarction 51 % (n=1331)
08 Vaginal bleeding decreases over time with a levonorgestrel intrauterine system 57 % (n=1363)
07 USPSTF 2020 recommends education/counseling to prevent tobacco use in children and adolescents (B recommendation) 55 % (n=1241)
06 USPSTF 2020 recommends against screening for BV in pregnant women who are not at risk for preterm labor (D recommendation) 40 % (n=1294)
03 Urgent endoscopy for high-risk patients with acute upper gastrointestinal bleeding does not reduce mortality 32 % (n=1330)
02 Transcatheter aortic valve replacement outcomes are similar to surgical aortic valve replacement outcomes at 5 years 27 % (n=1303)
01 The STOPPFrail criteria decreases medication use and costs without short-term harms 55 % (n=1344)
Juin  
30 Self-diagnosis of uncomplicated urinary tract infections usually confirmed and treated via telemedicine visits 59 % (n=1397)
29 There is little data about the usefulness of mobile device applications for managing children with autism spectrum disorder 24 % (n=1235)
26 Multiple randomized controlled trials fail to show the effectiveness of migraine chemoprophylaxis in children and adolescents 40 % (n=1312)
25 Cycled hyperbaric oxygen improves the healing of diabetic foot ulcers 30 % (n=1289)
24 The daily application of emollients during infancy does not prevent eczema (BEEP) 50 % (n=1400)
23 Aspirin is no different than other anticoagulants for VTE prevention after joint replacement surgery 40 % (n=1414)
22 Acupuncture is effective for the prevention of migraine without aura 47 % (n=1421)
20 COVID-19 research briefs: Remdesivir speeds recovery in patients with COVID-19 29 % (n=1316)
19 All methods are reasonable for the management of early miscarriage 48 % (n=1374)
18 For patients with ARDS, conservative oxygen strategy is no better, and may be worse, than a more liberal strategy (LOCO2) 18 % (n=1272)
17 Surgery appears to improve outcomes more than usual care in patients with sciatica for more than 4 months 50 % (n=1385)
16 Behavioral therapy better than drug therapy for overactive bladder in men 53 % (n=1368)
15 Guidelines for obstructive sleep apnea and insomnia from the US Departments of Defense and Veteran Affairs 60 % (n=1237)
14 COVID-19 research briefs: remdesivir shortens recovery time 28 % (n=1357)
13 COVID-19 research briefs: flawed trial means it remains unclear how 10-day and 5-day remdesivir treatment compare 23 % (n=1297)
12 Nonsedation of mechanically ventilated patients does not improve outcomes compared with light interrupted sedation 16 % (n=1238)
11 Conservative oxygen strategy provide no clear benefit in mechanically ventilated patients 14 % (n=1195)
10 Intracervical block with 2% lidocaine reduces pain associated with LNG-IUS placement 35 % (n=1340)
09 Terbinafine and itraconazole are most effective for toenail onychomycosis 63 % (n=1483)
08 Laboratory results are not an exact science 72 % (n=1452)
07 COVID-19 research briefs: social factors and co-morbidity may explain apparent higher mortality in Black people 31 % (n=1248)
06 COVID-19 research briefs:current treatment for cancer does not increase COVID-19 mortality and convalescent plasma safe 36 % (n=1323)
05 A specific probiotic decreases crying in colicky infants younger than 2 months 47 % (n=1415)
04 Low-dose aspirin beneficial for the prevention of preterm birth in nulliparas with singleton pregnancy 23 % (n=1405)
03 17-OHPC may not reduce recurrent preterm birth or decrease neonatal morbidity 20 % (n=1207)
02 Plaster casts no better than functional braces in patients with nonoperative treatment of Achilles ruptures 32 % (n=1426)
01 GLP-1 agonists associated with lower stroke risk in patients with type 2 diabetes at high risk for cardiovascular disease 53 % (n=1327)
Mai  
31 COVID-19 research briefs: stay-at-home and social distancing policies are effective at reducing the spread of SARS-CoV-2 74 % (n=838)
30 COVID-19 research briefs: hydroxychloroquine, chloroquine, azithromycin not associated with benefit and may increase harms 48 % (n=9)
29 Antibiotic and corticosteroid treatment effective for acute exacerbations of COPD 69 % (n=1481)
28 3% nebulized hypertonic saline equals standard supportive care in children with moderate or severe bronchiolitis 28 % (n=1293)
27 Limited evidence on the long-term prescribing of opioids in elders 53 % (n=1362)
26 Flu vaccine does not increase fever frequency when added to the 12- to 16-month vaccine line-up 50 % (n=1411)
25 AAN guideline for treating insomnia in children and adolescents with autism spectrum disorder 35 % (n=1313)
24 COVID-19 research briefs: asymptomatic carriage during pregnancy is common, and unclear efficacy evidence for homemade masks 58 % (n=1430)
23 COVID-19 research briefs: mortality 21% for hospitalized patients in New York City, and transmission in a restaurant in China 49 % (n=1410)
22 Increased daily steps associated with reduced all-cause mortality 69 % (n=1544)
21 Medication, hypnosis, therapeutic suggestion, and CBT can decrease pain and opioid use 55 % (n=1388)
20 USPSTF 2020 recommends screening for hepatitis C virus infection in adolescents and adults aged 18 to 79 (B recommendation) 57 % (n=1444)
19 Mortality rate in patients with recent ACS and endoscopy is similar to that in patients with ACS and no endoscopy 24 % (n=1404)
18 C-reactive protein is the most useful biomarker for diagnosis of outpatient community-acquired pneumonia 56 % (n=1616)
17 COVID-19 research briefs: Antihypertensive use not associated with an increased risk of SARS-CoV-2 infection 54 % (n=1548)
16 COVID-19 research briefs: SARS-CoV-2 may increase stroke rate in patients younger than 50, and remdesivir shortens recovery 35 % (n=955)
15 Clinical assessment of signs and symptoms still guides cellulitis diagnosis 65 % (n=1486)
14 Lower costs and healthcare utilization with hospital care at home 34 % (n=1337)
13 Watch-and-wait strategy is an option for primary spontaneous pneumothorax 34 % (n=1471)
12 For mild to severe COPD exacerbations, antibiotics and steroids remain the mainstay of treatment 69 % (n=1551)
11 No mortality benefit, increased risk of acute kidney injury with addition of beta-lactam to usual therapy for MRSA bacteremia 29 % (n=1139)
10 COVID-19 research briefs: Wuhan patient outcomes, and new Infectious Disease Society of America treatment guidelines 34 % (n=1027)
09 COVID-19 research briefs: anosmia common in SARS-CoV-2 infection, and a negative trial of hydroxychloroquine 49 % (n=1491)
08 COVID-19 research briefs: 44% of secondary infections of SARS-CoV2 occur when the index case is presymptomatic 66 % (n=1567)
07 COVID-19 research briefs: a damp washcloth may reduce the number of aerosolized droplets generated by speech 43 % (n=1521)
06 COVID-19 research briefs: useful tools to support telehealth during COVID-19 lockdown 62 % (n=1349)
05 COVID-19 research briefs: case series shows early promise for remdesivir 33 % (n=1480)
04 COVID-19 research briefs: SR shows consistent benefit of quarantine measures to reduce the spread of an epidemic 77 % (n=1569)
01 COVID-19 research briefs: very small prospective study shows no benefit of hydroxychloroquine plus azithromycin 41 % (n=1483)
Avril  
30 Have the USPSTF recommendations against screening caused more aggressive prostate cancer? 52 % (n=1414)
29 American College of Rheumatology guideline for managing patients with degenerative joint disease of the hand, knee, and hip 63 % (n=1363)
28 British Society for Rheumatology guideline on managing patients with giant cell arteritis 44 % (n=1362)
27 Three RCTs: neither minocycline nor lanabecestat is better than placebo to treat patients with mild Alzheimer disease 37 % (n=1405)
26 COVID-19 research briefs: prediction models for COVID-19 have important limitations 42 % (n=1547)
25 COVID-19 research briefs: small trial of lopinavir-ritonavir for patients hospitalized with COVID-19 shows no benefit 33 % (n=1526)
24 USPSTF 2020 does not recommend for or against screening for cognitive impairment in older adults (I recommendation) 55 % (n=1431)
23 High risk of recurrent postpartum mental disorders 51 % (n=1493)
22 Uncertain benefit of home noninvasive positive pressure ventilation for adults with chronic obstructive pulmonary disease 29 % (n=1364)
21 Similar long-term morbidity and mortality with human insulin and analogue insulins 54 % (n=1403)
20 Consensus guideline recommends screening for some persons at high risk for pancreatic cancer 31 % (n=1439)
19 COVID-19 research briefs: case series of critically ill patients in the intensive care unit 42 % (n=1681)
18 COVID-19 research briefs: handwashing reduces transmission of respiratory infections 82 % (n=1716)
17 Vitamin D supplementation during pregnancy does not prevent asthma in offspring 38 % (n=1539)
16 Treating H. pylori infection in close relatives of patients with gastric cancer prevents gastric cancer 36 % (n=1542)
15 Volume-based low-dose CT screening reduces lung cancer–specific mortality (NELSON) 50 % (n=1426)
14 Perineorrhaphy successful for treatment of poorly healed second-degree perineal laceration 23 % (n=1178)
13 PPIs and H2 receptor blockers reduce the risk of GI bleeding in high-risk, critically ill patients 35 % (n=1604)
12 COVID-19 research briefs: (3) Guidance for remote (telehealth) management (25 March 2020) 66 % (n=1498)
11 COVID-19 research briefs: (1) a case series of convalescent sera, and (2) a negative trial of hydroxychloroquine 47 % (n=1671)
10 Fecal microbiota transplant effective for irritable bowel syndrome 43 % (n=1627)
09 Daily colchicine post-MI reduces strokes and recurrent hospitalizations for angina (COLCOT) 44 % (n=1515)
08 Isolated diastolic hypertension not associated with increased risk of CVD 61 % (n=1521)
07 Prostatectomy for localized prostate cancer causes more functional problems without any survival benefit 44 % (n=1397)
06 Increased vegetable consumption does not decrease prostate cancer progression 39 % (n=1491)
03 Denosumab no better than bisphosphonates at preventing fracture, and the cost is much higher 56 % (n=1438)
02 Powder use in the genital area is not associated with an increased risk of ovarian cancer 35 % (n=1531)
01 When every drop counts: tapping beer cans does not lessen the volume lost upon opening 23 % (n=16)
Mars  
31 Nearly 50% of children with severe asthma no longer meet the criteria for severe disease after 3 years 50 % (n=1444)
30 Omalizumab is better than placebo in alleviating symptoms in kids with severe atopic dermatitis (ADAPT) 26 % (n=1287)
27 Pragmatic trial: Oseltamivir of uncertain benefit in patients with flu-like symptoms 57 % (n=1419)
26 Extended follow-up: anastrozole better than placebo to prevent breast cancer in high-risk women (IBIS-II) 38 % (n=1323)
25 Melatonin is no more effective than placebo to prevent delirium after major cardiac surgery 20 % (n=1431)
24 Physiotherapy plus usual care is equal to usual care in kids with functional constipation 40 % (n=1369)
23 Whether warfarin is taken in the morning or the evening makes no meaningful difference in time in therapeutic range 60 % (n=1521)
20 European guidelines on breast cancer screening 2020 53 % (n=1371)
19 Acetaminophen (paracetamol) is no better than placebo for most pain, except maybe tension headache 69 % (n=1488)
18 American College of Physicians: Limit testosterone supplementation in older men to the treatment of sexual function issues 46 % (n=1316)
17 Elagolix with add-back therapy effective for premenopausal heavy menstrual bleeding associated with fibroids 26 % (n=1143)
16 Folic acid and zinc supplementation does not improve semen quality or increase live birth rate 27 % (n=1310)
13 Small reduction in CV outcome after ischemic stroke with lower LDL target, but also harms; no change in all-cause mortality 47 % (n=1223)
12 A program involving family members reduces postoperative delirium in elderly patients 41 % (n=1317)
11 Mailing FIT or gFOBT directly to patients increases uptake of colorectal cancer screening 59 % (n=1493)
10 Ibuprofen postpartum does not increase blood pressure for women with mild hypertensive disorders of pregnancy 37 % (n=1449)
09 Newborns with feeding difficulty may not need frenotomy 40 % (n=1475)
06 Automated text reminders to take blood pressure medications do not improve hypertension control 48 % (n=1459)
05 No clear advantage to balanced crystalloids over saline; though 1 study suggests a mortality benefit in patients with sepsis 35 % (n=1479)
04 Increasing the D-dimer threshold for patients with low clinical pretest probability effectively rules out PE (PEGeD) 41 % (n=1435)
03 No difference in unplanned secondary procedures after initial THA versus hemiarthroplasty for hip fractures in elderly 25 % (n=1360)
02 Mohs similar to wide excision in observational study of patients with stage I melanoma (most < 0.8 mm thickness) 26 % (n=1387)
Février  
28 Surgery for clavicular fractures provides better outcomes but more harms than conservative treatment 35 % (n=1596)
27 MA: intra-articular corticosteroids provide short-term relief in patients with adhesive capsulitis 53 % (n=1547)
26 Irbesartan slows aortic dilation, but doesn't reduce the rate of surgery in those with Marfan syndrome (AIMS) 17 % (n=1449)
25 No cow's milk formula for the first 3 days of life prevents food allergies 45 % (n=1625)
24 Counseling is equal to varenicline to help adolescents quit smoking 47 % (n=1426)
21 Rates of adverse effects of treatment for otitis media varies by antibiotic and dose 60 % (n=1498)
20 Useful signs and symptoms for diagnosing hip osteoarthritis 62 % (n=1548)
19 Antibiotic use associated with a risk of cardiovascular disease in adult women 60 % (n=1593)
18 Frozen embryo transfer associated with increased risk of childhood cancer 21 % (n=1542)
17 USPSTF 2019 still recommends one-time AAA screening with US in men 65 years or older who have ever smoked (B recommendation) 59 % (n=1596)
15 Initial information about the novel coronavirus in Wuhan, China 43 % (n=1615)
14 Vaccine prevents active tuberculosis in adults with latent tuberculosis (NNT = 333 over 3 years) 19 % (n=1466)
13 Supplemental MRI screening in women with very dense breasts reduces interval cancer rate but may cause overdiagnosis (DENSE) 46 % (n=1483)
12 Ubrogepant modestly effective for acute migraine, but safety and a lack of comparison with triptans are concerning 35 % (n=1350)
11 MAb114 and REGN-EB3 preferred over ZMapp and remdesivir for the treatment of Ebola virus disease (PALM) 8 % (n=1301)
10 Neonatal early-onset sepsis calculator associated with decreased antibiotic use and no increase in sepsis 16 % (n=1318)
07 Comparable benefits and harms of anticoagulant and antiplatelet treatment in patients with PFO and cryptogenic stroke 26 % (n=1414)
06 Unclear whether blue light is effective in treating acne vulgaris 31 % (n=1487)
05 Risk prediction model predicts VTE recurrence after initial thrombotic event 37 % (n=1455)
04 In patients with prior stroke and hypertension, lower BP target no more effective in preventing recurrent strokes (RESPECT) 56 % (n=1594)
03 Another "-gepant"—ubrogepant —is somewhat effective for acute migraine (NNT = 13) 37 % (n=1400)
Janvier  
31 Oral CBD promising for treatment of heroin use disorder 19 % (n=1530)
30 No benefit to treatment of subclinical hypothyroidism in adults 80 years and older 59 % (n=1673)
29 Very expensive lefamulin is no worse than moxifloxacin for community-acquired pneumonia 38 % (n=1491)
28 Smartwatch app can detect atrial fibrillation in some patients, but its impact on health outcomes unclear 39 % (n=1510)
27 Dapagliflozin reduces mortality and hospitalization rates for patients with mild heart failure and reduced ejection fraction 45 % (n=1481)
24 Being a former professional soccer player is associated with an increased risk of neurodegenerative disease 20 % (n=1578)
23 Ticagrelor alone was associated with less bleeding than ticagrelor plus aspirin, but aspirin alone was not evaluated 40 % (n=1413)
22 Lower risk of early ventilator-associated pneumonia with antibiotics in patients with out-of-hospital cardiac arrest 17 % (n=1398)
21 Trade-offs between short- and long-term outcomes for PCI and CABG in left main coronary artery disease (EXCEL) 37 % (n=1465)
20 Treatment of osteoporosis is not associated with increased longevity 54 % (n=1626)
17 Medical cannabis use not supported by a wealth of research 60 % (n=1728)
16 Nonpharmacologic approaches are better than medication to control aggression/agitation in dementia 49 % (n=1644)
15 Mind-body treatments enhance opioid treatment of patients with acute or chronic pain 55 % (n=1549)
14 American College of Physicians: Screen for colon cancer using the test the patient chooses 62 % (n=1566)
13 Sertraline slightly reduces symptoms of depression and provides other benefits in primary care 66 % (n=1703)
10 Optimal step-up therapy for black children and adults with poorly controlled asthma 37 % (n=1416)
09 No short-term extra benefit when muscle relaxants are added to ibuprofen for acute low back pain 68 % (n=1734)
08 For 3-vessel disease (but not left main disease), CABG is preferred over PCI 35 % (n=1533)
07 Acupuncture decreases frequency and intensity of angina 29 % (n=1513)
06 Complete revascularization after STEMI leads to fewer recurrent Mis 36 % (n=1512)
03 Elective induction of labor at 39 weeks associated with decreased cesarean rate 25 % (n=1453)
02 Planned delivery for late preterm preeclampsia reduces maternal morbidity 20 % (n=1421)
01 Autism screening with follow-up overidentifies autism spectrum disorder 38 % (n=1473)
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