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Question clinique
Is the addition of clopidogrel or ticagrelor more effective than aspirin alone in preventing recurrent stroke or death in persons with recent minor ischemic stroke or transient ischemic attack?
L’Essentiel
Dual antiplatelet therapy, either with clopidogrel or ticagrelor, is more effective than aspirin monotherapy in preventing recurrent stroke but not death in adults with a recent minor stroke or transient ischemic attack. 1a
Référence
Plan de l'etude: Meta-analysis (randomized controlled trials)
Financement: Unknown/not stated
Cadre: Various (meta-analysis)
Sommaire
These authors searched MEDLINE, Embase, the Cochrane Registry of Clinical Trials, and the last 20 years of abstracts from international stroke conferences to identify randomized trials that included persons with minor stroke or transient ischemic attacks who were randomized into one of the following comparison groups: ticagrelor and aspirin vs aspirin; clopidogrel and aspirin vs aspirin; or ticagrelor and aspirin vs clopidogrel and aspirin. The inclusion criteria also included at least 30 days of follow-up and an assessment of recurrent stroke and death. They authors included 9 studies (N = 22,098) with 4 subgroup analyses, and all were at low risk of bias. The treatment duration ranged from 21 days to 90 days. The authors pooled the study data and conducted a network meta-analysis. Compared with aspirin monotherapy, the primary outcome (a composite of recurrent ischemic stroke or death within 90 days of enrollment) was less frequent in both dual therapy groups (clopidogrel + aspirin [hazard ratio (HR) 0.74; 95% credible interval (CrI) 0.65 - 0.84]; ticagrelor + aspirin [HR 0.79; 0.68 - 0.91]). Most of the benefit was in ischemic stroke prevention (HR 0.71; 0.62 - 0.82 and 0.74; 0.64 - 0.86, respectively) as there was no statistically significant difference in 90-day mortality in any of the groups. Additionally, dual therapy with clopidogrel and dual therapy with ticagrelor were each associated with a lower risk of functional disability at 90 days (HR 0.82; 0.74 - 0.91 and 0.85; 0.75 - 0.97, respectively). Although dual therapy was associated with more frequent major hemorrhage, the clopidogrel plus aspirin group had fewer events than the ticagrelor plus aspirin group (HR 1.78; 1.09 - 2.92 and 2.63; 1.51 - 4.82, respectively). The authors do not present the data in a manner that allows for estimation of numbers needed to treat.
Reviewer
Henry C. Barry, MD, MS
Professor
Michigan State University
East Lansing, MI
Commentaires
DAPT in stroke
Any time limitations ?
doap
plavix asa
dual APT and reducing strokes
asa plus either tigagrlor or clopidogrel more effective in preventing recurrent strokes