Risperidone and paliperidone are less effective and more harmful than shown in published studies

Question clinique

Are the reported benefits and harms of risperidone and paliperidone different when the results of unpublished studies are included?

L’Essentiel

The published literature presents a misleading picture of the potential benefits and harms of risperidone and paliperidone. The addition of unpublished clinical trial reports indicates less benefit (especially for risperidone) and more adverse events. Clinical trial registries like the Yale Open Data Access project are a good start, but full transparency of all clinical trial reports with full access by independent researchers to de-identified data is needed. 1a

Plan de l'etude: Meta-analysis (randomized controlled trials)

Financement: Government

Cadre: Outpatient (any)

Reviewer

Mark H. Ebell, MD, MS
Professor
University of Georgia
Athens, GA


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Commentaires

Howard David Koseff

Confirmation of what we know

Geriatrician alert!

Anonymous

Risperidone / Paliperidone Studies

Suspect this type of review would call into question Pharma's other medication claims.

Anonymous

risperidone/paliperidone

chronic rx may have more harms then benefits