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Question clinique
Does prenatal exposure to triptans increase the risk of diagnosis and symptoms of attention-deficit/hyperactivity disorder among offspring?
L’Essentiel
The maternal use of triptans during pregnancy is not associated with an increased risk of the diagnosis or symptoms of ADHD in offspring. 2b
Référence
Plan de l'etude: Cohort (prospective)
Financement: Foundation
Cadre: Population-based
Sommaire
These investigators analyzed data from multiple Norwegian health registries — including a birth registry, patient registry, and prescription database — from 1999 to 2008. The study sample included women who reported migraines or triptan use during the first trimester or before pregnancy only (n = 10,167) or who filled a triptan prescription during the 6 months before pregnancy. Identification of children with the diagnosis or symptoms of attention-deficit/hyperactivity disorder (ADHD) occurred through chart review and prescription dispensation. In addition, the children of study parents underwent behavioral assessment using a standard ADHD scoring tool at age 5 years. Multiple adjustments occurred for covariates, including maternal age, parity, marital status, education level, income, prepregnancy body mass index, folic acid use, smoking, alcohol use, maternal and paternal ADHD medication use, parental symptoms of anxiety and depression, and parental life satisfaction. Follow-up occurred for a mean of 10.6 years. Prenatal exposure to triptans was not significantly associated with an increased risk of ADHD diagnosis or symptoms.
Reviewer
David C. Slawson, MD
Professor and Vice Chair of Family Medicine for Education and Scholarship
Atrium Health
Professor of Family Medicine, UNC Chapel Hill
Charlotte, NC
Commentaires
Good knowledge
Reassuring to know there's no connection between tryptin use during pregnancy and ADHD in the children