Intensive urate lowering for erosive gout is difficult to achieve and does not improve outcomes

Question clinique

Does intensive urate lowering improve outcomes in persons with erosive gout?

L’Essentiel

In adults with erosive gout, intensive urate lowering is difficult to achieve, takes a lot of medications, and does not improve outcomes. 1b-

Plan de l'etude: Randomized controlled trial (double-blinded)

Financement: Government

Cadre: Outpatient (specialty)

Reviewer

Henry C. Barry, MD, MS
Professor
Michigan State University
East Lansing, MI


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Commentaires

A PRAGATHESWARAN

Uricosuric agent

Any amount of increasing the doses of uricosuric agent has little effect on the outcome of management of erosive gouty arthritis

Pieter Richard Verbeek

Intensive therapy for erosive gout

It makes sense that the target uric acid level for intensive therapy was lower than for the standard therapy group. It is nevertheless curious that only 53% of the intensive therapy group achieved the target compared with 83% of the standard therapy group. One wonders what % of the intensive therapy group actually achieved the targeted standard therapy level.

Anonymous

intensive lowering of urate

does not improve outcomes in erosive gout