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Fasting and nonfasting lipid levels similarly predict CVD risk
Question clinique
Are fasting lipid levels more predictive of cardiovascular outcomes than nonfasting lipid levels?
L’Essentiel
Guidelines recommend checking lipid levels in nonfasting patients. They are easier to obtain and, as this study found, are equally predictive of subsequent cardiac events. Although triglyceride levels may be higher in nonfasting patients, cholesterol levels will be similar whether the patient was fasting or not. 2c
Référence
Plan de l'etude: Cohort (retrospective)
Financement: Industry + govt
Cadre: Outpatient (any)
Sommaire
This study looked at 8270 patients enrolled in a clinical trial of cholesterol lowering. The patients were between the ages of 40 years and 79 years with hypertension and a total untreated cholesterol level of less than 250 mg/dL (6.5 mmol/L) with 3 additional risk factors for cardiovascular disease. The authors obtained nonfasting and fasting lipid levels, 4 weeks apart, during the baseline period of the study. The average fasting and nonfasting total cholesterol and HDL cholesterol levels were similar. Triglyceride levels were modestly higher (25 mg/dL; 0.28 mmol/L) when measured in nonfasting patients. The hazard ratios, which in this case measured of the cumulative risk of having a major coronary event within 3.3 years, were similarly associated with fasting and nonfasting cholesterol levels. Results were similar for patients with and without previous cardiovascular disease and in treated and nontreated patients.
Reviewer
Allen F. Shaughnessy, PharmD, MMedEd
Professor of Family Medicine
Tufts University
Boston, MA
Commentaires
non fasting lipid!!
This poem Changed my practice