À compter du 1er décembre 2023, l’accès à POEMs et à Essential Evidence Plus ne fera plus partie des avantages offerts aux membres de l’AMC.
Question clinique
Does vitamin D supplementation reduce the risk of recurrent wheezing in black infants born preterm?
L’Essentiel
Vitamin D supplementation (400 IU daily) reduces the risk of parent-reported recurrent wheezing in black infants born prematurely. Supplementation did not reduce the risk of asthma, respiratory sick visits, allergies, eczema, emergency department visits, or hospitalization. 1b
Référence
Plan de l'etude: Randomized controlled trial (double-blinded)
Financement: Government
Cadre: Outpatient (primary care)
Sommaire
Black infants born preterm experience high rates of wheezing throughout infancy. These investigators enrolled 300 infants who were 28 (0/7) to 36 (6/7) weeks' gestational age at birth, identified by the family as black or African American, and who received 28 days or less of supplemental oxygen during hospitalization. Eligible infants, adjusted gestational age 40 (6/7) weeks or younger at enrollment, received open-label vitamin D supplement 400 IU daily until consuming at least 200 IU in formula or human milk fortifier. Infants were then randomized (concealed allocation assignment) to continue vitamin D 400 IU daily or placebo. Parents, caregivers, and study personnel remained masked to treatment group assignment. Complete follow-up occurred at 12 months of age for 94.0% of participants. Using intention-to-treat analysis, parent-reported recurrent wheezing (2 or more episodes) with or without an infection occurred significantly less in the sustained supplementation group than in the control group (31.1% vs 41.8%, respectively; number needed to treat = 9.4, 95% CI 3.6 - 34.5). No significant group differences occurred in other medically reported illnesses such as asthma, allergies, eczema, respiratory sick visits, emergency department visits, hospitalizations, or adverse events.
Reviewer
David C. Slawson, MD
Professor and Vice Chair of Family Medicine for Education and Scholarship
Atrium Health
Professor of Family Medicine, UNC Chapel Hill
Charlotte, NC
Commentaires
I think vitamin D is trying too hard to find an indication...........
So basically it is ineffective for preventing respiratory events. That should have been the focus of POEM, not parent reported wheezing
I have every bay on vitamin D
Publish or perish.
Good poem