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Question clinique
Does the use of hydrolyzed infant formula reduce the risk of type 1 diabetes in children with genetic disease susceptibility?
L’Essentiel
This study found no significant difference in the risk of developing type 1 diabetes in children with genetic susceptibility with the use of a hydrolyzed infant formula compared with a conventional cow's milk–based formula. 1b
Référence
Plan de l'etude: Randomized controlled trial (double-blinded)
Financement: Foundation
Cadre: Population-based
Sommaire
Evidence from pathophysiologic and observational studies suggest that exposure to certain proteins in early infancy may increase the risk of type 1 diabetes in children with a genetic susceptibility. These investigators identified newborn infants considered to be at high risk for type 1 diabetes because of a first-degree relative with type 1 diabetes and a specific human leukocyte antigen genotype. All mothers were encouraged to initially breastfeed as long as individually desired. In both groups, 50% to 60% of mothers breastfed over 6 months. Eligible infants randomly received (concealed allocation) assigned weaning to either an extensively hydrolyzed casein-based formula or a control formula composed of 80% intact cow's milk protein and 20% hydrolyzed milk protein. Both formulas had a similar taste and smell. Individuals who assessed outcomes remained masked to treatment group assignment. Complete follow-up occurred for 97% of participants for a median of 11.5 years. Using both intention-to-treat and per-protocol (exposure to the study formula for 60 days or longer and no exposure to bovine protein foods) analyses, no significant difference occurred in the development of type 1 diabetes in the intervention versus conventional formula group (8.4% vs 7.6%). There was also no significant difference in the median age at diagnosis. Similar linear growth and weight gain occurred in both treatment groups.
Reviewer
David C. Slawson, MD
Professor and Vice Chair of Family Medicine for Education and Scholarship
Atrium Health
Professor of Family Medicine, UNC Chapel Hill
Charlotte, NC
Commentaires
Another useless study of the minimal effects of 6 months or less of dietary intervention failing to make a difference in outcomes 10 years later. I would think that it did not reduce obesity rates, either.
Milk Formula = PROCESSED Food
good poem