COVID-19 research briefs by Essential Evidence Plus (EE+)

COVID-19 research briefs by Essential Evidence Plus (EE+)

As the COVID-19 pandemic continues to evolve, the Joule team is working closely with Dr. Mark Ebell, Editor-in-Chief of EE+ and the team at Wiley Publishing to share current research summaries with physicians.

POEMs* subscribers will receive COVID-19 related research briefs on most weekends and on select weekdays. You can view these updates below, subscribe to receive daily POEMS, refer to the POEMs archive (cma.ca login required) to comment on these summaries or collect CPD credits, or refer to the Essential Evidence Plus COVID-19 website.

Essential Evidence Plus (EE+) is making relevant COVID-19 information freely available, to help physicians caring for patients around the world. Topic updates on Coronavirus SARS-CoV2 infection (COVID-19) are being made as new information becomes available.

Clinical Question

Is remdesivir safe and effective for the treatment of COVID-19?

Bottom line

Remdesivir provides a clinically and statistically significant reduction in the duration of symptoms of COVID-19. Questions remain regarding its effects on mortality and on patients who have advanced disease that requires mechanical ventilation or extracorporeal membrane oxygenation (ECMO). 1b

Clinical Question

Can remdesivir improve outcomes in people with COVID-19?

Bottom line

Remdesivir shortens recovery time in hospitalized patients with COVID-19 and lower respiratory tract infections (ACTT-1). 4

Author(s)

Henry C. Barry, MD, MS

Clinical Question

How does 10-day compare with 5-day treatment with remdesivir in people with COVD-19?

Bottom line

Outcomes similar for 5 vs 10 days remdesivir but trial had flaws. 1b

Author(s)

Mark H. Ebell, MD, MS

Clinical Question

Is mortality higher in Black people who develop COVID-19?

Bottom line

Adjusted in-hospital mortality from COVID-19 in Louisiana no different for Black and White patients. 2b

Author(s)

John Hickner, MD, MS

Clinical Question

Is risk of COVID-19-related mortality or morbidity higher in patients receiving biologic agents? Is convalescent plasma safe?

Bottom line

Patients taking biologic agents not at greater risk of poor outcomes. Patients receiving convalescent plasma have few transfusion-related serious adverse events. 4

Author(s)

Mark H. Ebell, MD, MS

Clinical Question

Do stay-at-home orders or social distancing policies reduce the spread of COVID-19?

Bottom line

Retrospective data suggest that the implementation of stay-at-home and social distancing policies in US counties slowed the spread of COVID-19. 4

Author(s)

John Hickner, MD, MS

Clinical Question

Can hydroxychloroquine, chloroquine, or azithromycin improve outcomes for patients with SARS-CoV-2 infection?

Bottom line

Hydroxychloroquine (HCQ), chloroquine, and azithromycin, used alone or in combination, do not reduce mortality in patients with COVID-19 and increase the risk of serious cardiac-related adverse events. 4

Author(s)

Henry C. Barry, MD, MS

Clinical Question

What is the rate of COVID-19 among asymptomatic pregnant women? Can homemade face masks prevent transmission of the virus?

Bottom line

The high rate of asymptomatic carriage of COVID-19 among pregnant women admitted to hospitals in New York suggests that COVID-19 spread will be difficult to contain with medical isolation, quarantine, and contact tracing only. There is equivocal evidence of effectiveness of face masks for preventing transmission. 4

Author(s)

John Hickner, MD, MS

Clinical Question

What was the outcome for patients hospitalized with COVID-19 in New York City in March/April 2020? Can a cluster of COVID-19 cases be linked to a small restaurant in China, despite table distancing?

Bottom line

COVID-19 infection had a high mortality rate in patients who were hospitalized in New York City during March/April 2020, especially in those who required mechanical ventilation. Investigators uncover possible transmission of COVID-19 in a restaurant in China despite a distance of 1 meter (3 feet) among tables. 4

Author(s)

John Hickner, MD, MS

 

 

*DisclaimerPOEMs stands for Patient-Oriented Evidence that Matters. POEMs is a publication of John Wiley and Sons, Inc. and distributed by Joule as a CMA Member service. All content is provided for information and education and not as a substitute for the advice of a physician. Joule assumes no responsibility or liability arising from any error or omission or from the use of any information contained herein.