COVID-19 research briefs by Essential Evidence Plus (EE+)

COVID-19 research briefs by Essential Evidence Plus (EE+)

As the COVID-19 pandemic continues to evolve, the Joule team is working closely with Dr. Mark Ebell, Editor-in-Chief of EE+ and the team at Wiley Publishing to share current research summaries with physicians.

POEMs* subscribers will receive COVID-19 related research briefs on most weekends and on select weekdays. You can view these updates below, subscribe to receive daily POEMS, refer to the POEMs archive (cma.ca login required) to comment on these summaries or collect CPD credits, or refer to the Essential Evidence Plus COVID-19 website.

Essential Evidence Plus (EE+) is making relevant COVID-19 information freely available, to help physicians caring for patients around the world. Topic updates on Coronavirus SARS-CoV2 infection (COVID-19) are being made as new information becomes available.

Clinical Question

What effect has COVID-19 had on the mortality rate in the United States between March and August 2020?

Bottom line

Between March and August 2020, the United States has experienced 20% more deaths than otherwise would have been expected, two-thirds of which were directly attributed to COVID-19. 2c

Clinical Question

How long do COVID-19 symptoms persist in people with mild to moderate infection?

Bottom line

Symptoms (weight loss, severe dyspnea or asthenia/fatigue, chest pain, palpitations, anosmia/ageusia, headache, cutaneous signs, arthralgia, myalgia, digestive disorders, fever, or sick leave) persist at 60 days for two-thirds of people with mild to moderate COVID infection. 2c

Clinical Question

How effective are tests for diagnosing COVID-19?

Bottom line

The sensitivity of polymerase chain reaction for detection of COVID-19 declines rapidly over time; rapid antigen tests lack sensitivity for diagnosing COVID-19. 2a

Author(s)

Mark H. Ebell, MD, MS

Clinical Question

Can data predict mortality in people hospitalized with COVID-19?

Bottom line

Clinical data and laboratory values can predict mortality in patients hospitalized with COVID-19. 2c

Author(s)

Henry C. Barry, MD, MS

Clinical Question

Can hydrocortisone improve outcomes for people who are critically ill with COVID-19?

Bottom line

Hydrocortisone likely reduces the need for organ support interventions in critically ill patients with COVID-19 2c

Author(s)

John Hickner, MD, MS

Clinical Question

Which factors increase the risk of transmission of SARS-CoV-2?

Bottom line

There was significant SARS-CoV-2 transmission among bus riders in China. People who have dined at a restaurant or visited a bar or coffee shop are more likely to have COVID-19. 2c

Author(s)

John Hickner, MD, MS

Clinical Question

Does risk of COVID-19 increase if women are pregnant?

Bottom line

This meta-analysis shows pregnant women are less likely to manifest COVID-19 symptoms but are more likely to need intensive care than nonpregnant women. 2a

Author(s)

Henry C. Barry, MD, MS

Clinical Question

Does COVID-19 increase the risk of thromboembolic events in high-risk patients?

Bottom line

Retrospective data suggests a high incidence of thrombotic events in hospitalized COVID-19 patients, particularly in patients with risk factors. 2c

Author(s)

Mark H. Ebell, MD, MS

 

 

*DisclaimerPOEMs stands for Patient-Oriented Evidence that Matters. POEMs is a publication of John Wiley and Sons, Inc. and distributed by Joule as a CMA Member service. All content is provided for information and education and not as a substitute for the advice of a physician. Joule assumes no responsibility or liability arising from any error or omission or from the use of any information contained herein.