Letrozole more efficacious than clomiphene for infertility treatment among individuals with polycystic ovarian syndrome

Clinical Question

Is letrozole superior to clomiphene for infertility treatment among individuals with polycystic ovarian syndrome?

Bottom line

This meta-analysis of randomized controlled trials showed that for individuals with PCOS, treatment of infertility with letrozole as compared with clomiphene citrate, resulted in higher rate of ovulation induction, more pregnancies, and more live births. The conclusions are less than certain due to the high risk of bias in some studies. 1a-

Study design: Meta-analysis (randomized controlled trials)

Funding: Self-funded or unfunded

Setting: Various (meta-analysis)

Reviewer

Linda Speer, MD
Professor and Chair, Department of Family Medicine
University of Toledo
Toledo, OH


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Comments

ARUP KUMAR DHARA

Impact assessment

Excellent