Biomarkers associated with greater risk of progression to MCI or dementia in adults with subjective cognitive decline

Clinical Question

Among persons with subjective cognitive decline, are Alzheimer biomarkers associated with a greater likelihood of progression to mild cognitive impairment or dementia?

Bottom line

In this meta-analysis, the presence of Alzheimer-associated biomarkers among adults with subjective cognitive decline was associated with an increased risk of progression to MCI or dementia. However, the overall progression risk was approximately 10% over 3 years and the biomarkers are not easily determined. 1a-

Study design: Meta-analysis (other)

Funding: Self-funded or unfunded

Setting: Various (meta-analysis)

Reviewer

Henry C. Barry, MD, MS
Professor
Michigan State University
East Lansing, MI


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Comments

Anonymous

Poor evidence

Markers for Alzheimer's disease are not that predictive of later developing the disease. Stigmata of the diagnosis would be a negative thing

ARUP KUMAR DHARA

Assessment

Very good