Still no evidence of increased cardiovascular risk with attention-deficit/hyperactivity disorder medications

Clinical Question

Do medications for the treatment of attention-deficit/hyperactivity disorder increase the risk of serious cardiovascular disease events in young adults and middle-aged adults?

Bottom line

Previous studies from JAMA and The New England Journal of Medicine found no evidence that ADHD medications increase the risk of serious cardiovascular events in young and middle-aged adults. This updated systematic review confirms this finding. 1a-

Study design: Systematic review

Funding: Foundation

Setting: Various (meta-analysis)


David C. Slawson, MD
Professor and Vice Chair of Family Medicine for Education and Scholarship
Atrium Health
Professor of Family Medicine, UNC Chapel Hill
Charlotte, NC

Discuss this POEM




no increase in cvs negative outcomes


ADHD meds safe in CVD, wow!

“In addition, no subgroup significance occurred for stimulant versus nonstimulant medications, male versus female gender, or in individuals with or without a history of CVD. Heterogeneity between studies was significant, but no evidence of publication bias was detected.”

Arup Kumar Dhara

Impact assessment

Very good