Betahistine is ineffective for the treatment of primary tinnitus

Clinical Question

Is betahistine effective for improving symptoms of primary tinnitus?

Bottom line

Betahistine, an antihistamine used in many countries but no longer approved for use in the United States, was ineffective at maximum dose to decrease patients’ self-reported symptoms of nonpulsatile tinnitus. This small study’s results support those of a Cochrane Systematic Review from 2018, which also failed to find evidence of benefit. 1b-

Study design: Randomized controlled trial (double-blinded)

Funding: Industry

Setting: Outpatient (any)


Allen F. Shaughnessy, PharmD, MMedEd
Professor of Family Medicine
Tufts University
Boston, MA

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Arup Kumar Dhara

Impact assessment