Prophylactic amoxicillin-clavulanate does not reduce mortality in patients with severe alcohol-related hepatitis

Clinical Question

In patients with severe alcohol-related hepatitis, does the addition of prophylactic amoxicillin-clavulanate to steroids reduce the risk of death compared with steroids alone?

Bottom line

The addition of prophylactic amoxicillin-clavulanate to steroids does not decrease mortality in patients hospitalized with severe alcohol-related hepatitis compared with steroids alone. 1b

Study design: Randomized controlled trial (double-blinded)

Funding: Government

Setting: Inpatient (any location) with outpatient follow-up

Reviewer

Nita Shrikant Kulkarni, MD
Assistant Professor in Hospital Medicine
Northwestern University
Chicago, IL


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Comments

ARUP KUMAR DHARA

Impact assessment

Excellent

Anonymous

PROPHYLACTIC AMOXICILLI0N-CLAVULANATE DOES NOT REDUCE MO

VERY GOOD REVIEW