Effective strategies for the prevention of preeclampsia and pregnancy-induced hypertension

Clinical Question

What is the comparative effectiveness of various prophylactic treatments for preeclampsia and pregnancy-induced hypertension?

Bottom line

LMWH, exercise, calcium supplementation, and aspirin all reduce the risk of preeclampsia and PIH. The authors found no significant differences among the effectiveness of these strategies. Vitamin D supplementation was associated with reduced risk in the subgroup of studies conducted in Asia. However, the authors also stated that the certainty of evidence for most comparisons was low because of inconsistency and imprecision. 1a-

Study design: Meta-analysis (randomized controlled trials)

Funding: Government

Setting: Various (meta-analysis)

Reviewer

Linda Speer, MD
Professor and Chair, Department of Family Medicine
University of Toledo
Toledo, OH


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Comments

DR ARUP KUMAR DHARA

Impact assessment

Excellent

Anonymous

PIH prevention

I await ALARM recommendation changes to stop relying on ASA as prevention.

Anonymous

preeclampsia

asa, calcium, exercise and LMWH may reduce preeclampsia