Maternal epilepsy is associated with worse birth outcomes

Clinical Question

Is epilepsy associated with worse maternal and/or infant outcomes?

Bottom line

This meta-analysis of 76 observational studies found that women with epilepsy have worse maternal and neonatal outcomes than women without epilepsy. This was true whether or not epilepsy was treated with an ASM. Taking an ASM was associated with worse neonatal outcomes than not taking. Polytherapy was associated with worse neonatal outcomes than monotherapy. The authors recommend co-management of these patients with an epilepsy specialist for counseling and medication optimization. 1b

Study design: Meta-analysis (other)

Funding: Unknown/not stated

Setting: Various (meta-analysis)

Reviewer

Linda Speer, MD
Professor and Chair, Department of Family Medicine
University of Toledo
Toledo, OH


Discuss this POEM


Comments

ARUP KUMAR DHARA

Impact assessment

Excellent

Anonymous

Not relevant to my practice.

Thanks.

Anonymous

EPILEPSY IN PREGNANCY

GOOD TO KNOW