Targeting different oxygen saturation goals for mechanically ventilated patients does not impact clinical outcomes

Clinical Question

For critically ill adults using mechanical ventilation, does targeting a lower, intermediate, or higher oxygen saturation affect clinical outcomes?

Bottom line

Targeting lower, intermediate, or higher oxygenation levels for critically ill adults using mechanical ventilation does not affect the number of ventilator-free days or the number of deaths in the short term. 1b

Study design: Randomized controlled trial (nonblinded)

Funding: Government

Setting: Inpatient (ICU only)

Reviewer

Nita Shrikant Kulkarni, MD
Assistant Professor in Hospital Medicine
Northwestern University
Chicago, IL


Discuss this POEM


Comments

Pieter Richard Verbeek

Targeting different oxygen saturation goals for mechanically

Not surprised there were no outcome difference given the minimal differences in SpO2 between the three groups. It would be interesting to know the outcomes of patients with SpO2100 since these would be the only patients at risk for hyperoxia which is the crux of the issue.

Anonymous

O2 saturation - ventilation

As per the reviewer's comments

Anonymous

lower or higher oxygen sat targets in icu pts

doesn't make much difference in outcome

Arup Kumar Dhara

Impact assessment

Very good