Doxycycline and (probably) minocycline do not stain teeth of children

Clinical Question

Do tetracyclines cause teeth staining or affect dental health in children younger than 8 years?

Bottom line

Doxycycline and probably minocycline are suitable for short-term use in children. There is no evidence that either doxycycline or minocycline causes teeth staining in children younger than 8 years when taken for less than 2 weeks. Staining can occur with tetracycline but at doses much higher than typically used.  2b

Study design: Meta-analysis (other)

Funding: Self-funded or unfunded

Setting: Various (meta-analysis)


Allen F. Shaughnessy, PharmD, MMedEd
Professor of Family Medicine
Tufts University
Boston, MA

Discuss this POEM


Arup Kumar Dhara

Impact assessment



Short course of Tetracyclines in kids does not cause enamel

Sheds new light on enamel staining in kids. Higher dose and longer duration is to be avoided


doxycycline and minocycline tooth staining

Good to know