No increased risk of esophageal cancer with nonerosive gastroesophageal reflux

Clinical Question

Are patients with nonerosive gastroesophageal disease at an increased risk of esophageal cancer as compared with the average population?

Bottom line

We can reassure our patients (and ourselves) that nonerosive GERD does not increase the likelihood of esophageal cancer. Erosive GERD, however, is associated with a doubled — but still low — risk of developing cancer, with the likelihood increasing over time. 1b

Study design: Cohort (prospective)

Funding: Foundation

Setting: Population-based


Allen F. Shaughnessy, PharmD, MMedEd
Professor of Family Medicine
Tufts University
Boston, MA

Discuss this POEM


Arup Kumar Dhara

Impact assessment



esophageal cancer with nonerrosive gastroesophageal reflex

good to know