Testosterone does not increase major adverse cardiac events, but does increase risk of AFib, PE, acute kidney injury, and arrhythmia (TRAVERSE)

Clinical Question

Is transdermal testosterone replacement safe in men with known heart disease or at high risk for heart disease?

Bottom line

Although the most serious cardiovascular events were not more common in this group of high-risk men using testosterone gel, there were higher incidence rates of acute kidney injury, atrial fibrillation, nonfatal arrhythmias, and pulmonary embolism. Testosterone supplementation should be used with caution, if at all, in men with a history of these conditions. 1b-

Study design: Randomized controlled trial (double-blinded)

Funding: Industry

Setting: Outpatient (any)

Reviewer

Mark H. Ebell, MD, MS
Professor
University of Georgia
Athens, GA


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Comments

Anonymous

Softest kind of "data"

This review basically showed no difference. The minuscule difference in dysrhythmias is not significant. As a urologist I was exposed to an industry and patient driven demand for supplementary testosterone therapy, and it rarely made much difference.

DR ARUP KUMAR DHARA

Impact assessment

Excellent

Anonymous

testosterone and cardiovascular effects

good information