Insufficient evidence that progestogen maintenance prolongs pregnancy after preterm labor

Clinical Question

Does progestogen maintenance therapy prolong pregnancy after an episode of preterm labor?

Bottom line

This meta-analysis of maintenance progestogen therapy after initial treatment for PTL was unable to determine that the benefit in prolonging labor or other outcomes is conclusive. Studies at low risk of bias showed less impact of treatment: Treatment outcomes were not statistically different from control outcomes. Larger high-quality randomized controlled trials are needed. One specific question that should be addressed in future studies is whether initiation of maintenance therapy within 48 hours is important.  1a-

Study design: Meta-analysis (randomized controlled trials)

Funding: Self-funded or unfunded

Setting: Various (meta-analysis)

Reviewer

Linda Speer, MD
Professor and Chair, Department of Family Medicine
University of Toledo
Toledo, OH


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Comments

ARUP KUMAR DHARA

Impact assessment

Excellent

Anonymous

INSUFFICIENT EVIDENCE THAT PROGESTOGEN MAITAINACE PROLONGS

GOOD TO KNOW