Paroxetine is an effective treatment for refractory erythema in adults with rosacea

Clinical Question

Is paroxetine (Paxil) an effective treatment for refractory erythema in adults with rosacea?

Bottom line

This study found that paroxetine, 25 mg daily, is effective for improving refractory erythema of rosacea, defined as rosacea persisting despite at least 3 months of currently accepted therapy. The individual symptoms of flushing and burning sensation significantly improved but telangiectasia and overall lesion counts did not. 1b-

Study design: Randomized controlled trial (double-blinded)

Funding: Foundation

Setting: Outpatient (any)


David C. Slawson, MD
Professor and Vice Chair of Family Medicine for Education and Scholarship
Atrium Health
Professor of Family Medicine, UNC Chapel Hill
Charlotte, NC

Discuss this POEM



Impact assessment


George Manuel Burden

Paroxetine for Rosacea

One less thing to be depressed about!


ssri's help hot flashes

as paxil can have lots of drug intetactions limited use


Side effects

Paroxetine is notorious for withdrawal side effects. I would be very reluctant to suggest it as an option, especially given there are better tolerated options


effective treatment for erythema

good to know