Majority of CIN2 regress in women aged 25 to 30 years

Clinical Question

Is watchful waiting a reasonable alternative to invasive treatment for 25- to 30-year-old women with cervical intraepithelial lesion grade 2?

Bottom line

For women aged 25 to 30 years old with biopsy-confirmed CIN2 and HPV type that is not 16, a large majority of lesions regress at least partially within 2 years without treatment. Watchful waiting may be appropriate. For women with HPV 16, only 51% had a partial or total regression of CIN2, suggesting that immediate treatment (LEEP) is warranted. The majority of progression or regression was evident at 12 months. 1b

Study design: Cohort (prospective)

Funding: Unknown/not stated

Setting: Outpatient (specialty)


Linda Speer, MD
Professor and Chair, Department of Family Medicine
University of Toledo
Toledo, OH

Discuss this POEM




diligence is still indicated


HPV subtypes

Good info on subtypes


watchfull waiting for CIN2 lesions

safe after 2 years, just to follow

Arup Kumar Dhara

Impact assessment i8

Very good