Children with uncomplicated UTIs treated with 10 days vs 5 days of antibiotics have fewer treatment failures (SCOUT)

Clinical Question

Can children with uncomplicated urinary tract infections be successfully treated with short courses of antibiotics?

Bottom line

In this study, standard-course therapy for children with UTI was superior to short-course therapy. However, the number needed to treat of 28 suggests that offering short-course therapy is not unreasonable, especially if there is good follow-up in the subsequent weeks. 1b

Study design: Randomized controlled trial (double-blinded)

Funding: Government

Setting: Outpatient (any)

Reviewer

Henry C. Barry, MD, MS
Professor
Michigan State University
East Lansing, MI


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Comments

Arup Kumar Dhara

Impact assessment

Excellent

Anonymous

UNCOMPLICATED UTI IN CHILDRENS

GOOD TO KNOW

Bertus Johannes Reitsma

outcome

N.B.: very high percentage reported for adverse effects !!

Anonymous

No

No

Pieter Richard Verbeek

Short course antibiotic for pediatric UTI

Interesting abstract. I would not have predicted that the absolute difference in treatment failure in the short course group (4.2% failure) would be so "high" compared to the long course group (0.6%). If the goal of treatment is successful eradication of infection then I would think the practice of relying on "good follow up" for short course patients would meet with limited success. This suggestion is worth a follow up study to assess its value.