Of 27 micronutrient supplements, only a few reduce mortality and cardiovascular risk

Clinical Question

Which nutritional supplements have demonstrated benefit on cardiovascular disease–related and overall mortality?

Bottom line

Supplementation with n-3 fatty acids, such as those found in fish oil and olive oil, slightly decreases the risk of cardiovascular outcomes. Coenzyme Q10 (CoQ10, ubiquinol) is associated with an overall decrease in mortality in patients with heart failure. Other common vitamins and minerals do not seem to affect any outcomes. Beta-carotene, once hailed for its antioxidant effect, is associated with increased overall mortality and cardiovascular outcomes. The evidence maps in the paper are works of art and are great for getting a quick summary of the myriad analyses. 1a

Study design: Meta-analysis (randomized controlled trials)

Funding: Foundation

Setting: Various (meta-analysis)

Reviewer

Allen F. Shaughnessy, PharmD, MMedEd
Professor of Family Medicine
Tufts University
Boston, MA


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Comments

ARUP KUMAR DHARA

Impact assessment

Very good

Anonymous

micronutrients

I would have liked all the micronutrients in the study named in the summary so I didn't have to go to the actual paper to find out which were actually examined.

Anonymous

CMA, please don't get rid of POEMS!

PLEASE don't get rid of POEMs, CMA. This is such a great clinical summary of updated studies. It is so valuable. Please reconsider and keep POEMS.