RSV vaccine is safe and effective in adults 60 years and older, but the absolute risk reduction is small

Clinical Question

How effective is a bivalent respiratory syncytial virus (RSV) vaccine at preventing RSV infection in adults 60 years and older?

Bottom line

The RSV vaccine is 67% effective, with an NNT of 472 to prevent any symptomatic infection. The investigators argue that this is still important at a population level because of prolonged shedding and potential transmission of RSV among older infected adults. 1b

Study design: Randomized controlled trial (double-blinded)

Funding: Industry

Setting: Population-based

Reviewer

Mark H. Ebell, MD, MS
Professor
University of Georgia
Athens, GA


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Comments

ARUP KUMAR DHARA

Impact assessment

Excellent