Imiquimod is effective for treatment of cervical intraepithelial neoplasia grade 2 or 3

Clinical Question

Is imiquimod effective for the treatment of cervical intraepithelial neoplasia grade 2 or 3?

Bottom line

This meta-analysis of 4 small studies suggests that imiquimod is effective for the treatment of cervical intraepithelial neoplasia grade 2 or 3. Larger randomized controlled trials are needed to verify the results and to establish optimal treatment protocol. Imiquimod may be preferred over excisional treatment by individuals who plan to bear children after treatment, by avoiding pregnancy complications related to a loop electrosurgical excision procedure. Note that imiquimod is an off-label treatment of cervical intraepithelial neoplasia.   1a-

Study design: Meta-analysis (randomized controlled trials)

Funding: Unknown/not stated

Setting: Various (meta-analysis)

Reviewer

Linda Speer, MD
Professor and Chair, Department of Family Medicine
University of Toledo
Toledo, OH


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Comments

ARUP KUMAR DHARA

Impact assessment

Excellent

Anonymous

IMIQUIMOD FOR CFERVICAL NEOPLASIA

FGOOD TO KNOW

Anonymous

imiquimod for cervical dysplasia

I wonder if there was any significant difference in side effects or results depending on whether the patient applied the treatment or the physician