Early treatment of gestational diabetes is modestly beneficial for neonatal and maternal outcomes

Clinical Question

Is early diagnosis and treatment of mothers at high risk for gestational diabetes beneficial for mothers or neonates?

Bottom line

This well-designed randomized controlled trial showed modest benefits of screening pregnant patients at high risk for GDM in early pregnancy and treating if positive. A composite adverse neonatal outcome was reduced in the early treatment group (NNT=18). Severe maternal perineal injury was also reduced in the early treatment group (NNT= 36). 1b

Study design: Randomized controlled trial (single-blinded)

Funding: Government

Setting: Population-based


Linda Speer, MD
Professor and Chair, Department of Family Medicine
University of Toledo
Toledo, OH

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Impact assessment



Units of measurement should include SI values

Units of measurement of blood glucose should be reported in SI as well as US units, for better communication to all


early treatment of gestational diabetes

good to know


Canadian blood sugar units

It would have been useful to present the blood sugar parameters in Canadian units since this is a Canadian medical article.