Atogepant prevents acute headaches in adults with chronic migraines

Clinical Question

Is atogepant (Qulipta) effective in reducing headache frequency in adults with chronic migraines?

Bottom line

Atogepant is more effective than placebo in preventing acute migraines in highly selected adults with chronic migraine. While it is unclear if atogepant is any better than other preventive therapies, it is certainly more expensive. 1b

Study design: Randomized controlled trial (double-blinded)

Funding: Industry

Setting: Outpatient (specialty)


Henry C. Barry, MD, MS
Michigan State University
East Lansing, MI

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Arup Kumar Dhara

Impact assessment