Semaglutide once weekly helps adolescents lose weight, but 4% developed acute cholelithiasis

Clinical Question

Is a weekly semaglutide injection a safe and effective way for obese adolescents to lose weight?

Bottom line

Semaglutide helps adolescents lose a clinically significant amount of weight. Whether that weight loss persists when the medication is discontinued is unknown, and there was a concerning increase in episodes of acute cholelithiasis, a known adverse effect of the drug. It is not clear whether the risk of acute cholelithiasis (also seen a study of patients taking dulaglutide) is caused by the medication or is a function of rapid weight loss. 1b

Study design: Randomized controlled trial (single-blinded)

Funding: Industry

Setting: Outpatient (any)

Reviewer

Mark H. Ebell, MD, MS
Professor
University of Georgia
Athens, GA


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Comments

Arup Kumar Dhara

Impact assessment

Very good

Anonymous

Semaglutide and weight loss

The whole approach is flawed.