Semaglutide once weekly helps adolescents lose weight, but 4% developed acute cholelithiasis

Clinical Question

Is a weekly semaglutide injection a safe and effective way for obese adolescents to lose weight?

Bottom line

Semaglutide helps adolescents lose a clinically significant amount of weight. Whether that weight loss persists when the medication is discontinued is unknown, and there was a concerning increase in episodes of acute cholelithiasis, a known adverse effect of the drug. It is not clear whether the risk of acute cholelithiasis (also seen a study of patients taking dulaglutide) is caused by the medication or is a function of rapid weight loss. 1b

Study design: Randomized controlled trial (single-blinded)

Funding: Industry

Setting: Outpatient (any)


Mark H. Ebell, MD, MS
University of Georgia
Athens, GA

Discuss this POEM


Arup Kumar Dhara

Impact assessment

Very good


Semaglutide and weight loss

The whole approach is flawed.