Perioperative gabapentin use after major surgery is associated with increased delirium

Clinical Question

Is the perioperative use of gabapentin associated with an increase in delirium in older adults?

Bottom line

The use of gabapentin following major surgery in adults 65 years and older is associated with an increased risk of delirium, pneumonia, and new antipsychotic use. The routine use of gabapentin for pain control in the perioperative period should be reconsidered. 2b

Study design: Cohort (retrospective)

Funding: Government

Setting: Inpatient (any location)

Reviewer

Nita Shrikant Kulkarni, MD
Assistant Professor in Hospital Medicine
Northwestern University
Chicago, IL


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Comments

Anonymous

Gabapentin

To bed avoided in the peri-operative period

Fred Mather

Gabapentin and delirium after surgery.

Suggests deprescribing for other non-critical medications prior to surgery.

Anonymous

No

N/a

Anonymous

Gabapentin Post-op

Confusing data & reviewers' comments

Sabir Saeed

excellant information relevant to my practice

I will be looking forward to use of Gabapentin in postoperative pain management

Eric Nicholas Kaziuka

Perioperative use of gabapentin

I would like to see a study that indicates the usefulness of gabapentin in perioperative pain control. It's use in sciatica although wide spread in orthopedics and ER departments, has never been found effective in studies.

Anonymous

gabapentin in perioperative pain treatment

too many adverse rx's

ARUP KUMAR DHARA

Impact assessment

Very good