Older treatments for type 2 diabetes do not affect patient-oriented outcomes

Clinical Question

What treatments for type 2 diabetes decrease the likelihood of patient-oriented outcomes?

Bottom line

This study further separates the effect of diabetes treatments on blood glucose levels and important outcomes. SGLT-2 inhibitors and GLP-1 receptor agonists reduce all-cause and cardiovascular mortality, as well as other cardiac-related problems. Older treatments, including insulin, do not affect long-term outcomes. In what might result in a shake-up in our approach to type 2 diabetes, metformin was not found to be more effective than standard treatment to prevent important outcomes, which echoes previous findings and may cause it to be removed as a cornerstone of treatment 1a-

Study design: Meta-analysis (randomized controlled trials)

Funding: Foundation

Setting: Various (meta-analysis)


Allen F. Shaughnessy, PharmD, MMedEd
Professor of Family Medicine
Tufts University
Boston, MA

Discuss this POEM



Impact assessment



Too short

I can’t see that a 6 month follow up can be that meaningful


Studies too short

These studies were all 6 mos or less? How can that tell us the long term usefulness of these meds in a chronic disease?


Je suis d'accord avec les…

Je suis d'accord avec les précédents commentaires. 6 mois de suivi n'est pas assez long