Moderate or better evidence for specific cannabinoids for chronic pain, Tourette, epilepsy, spasticity, sleep, Parkinson, and other conditions

Clinical Question

How effective are cannabinoids for a broad range of medical conditions?

Bottom line

The best evidence supports the use of dronabinol and nabiximols for chronic pain, nabiximols for spasticity, cannabidiol for epilepsy, dronabinol for Tourette syndrome and Parkinson disease, and nabiximols for sleep, substance use disorder, and depression. 1a

Study design: Meta-analysis (randomized controlled trials)

Funding: Government

Setting: Outpatient (any)

Reviewer

Mark H. Ebell, MD, MS
Professor
University of Georgia
Athens, GA


Discuss this POEM


Comments

Bertus Johannes Reitsma

effectiveness MC

the main indications for MC with high effectiveness is in OA and RA.
Chronic pain patient category should have been specified in OA and RA only.
Not mentioned in this study is the paediatric patient group of autism that also have high effectiveness but should be studied separately of course

Anonymous

cannabis variants in therapeutics

Very interesting to see hard evidence that cannabis products have efficacy in many chronic conditions.

Anonymous

mmj

usefull sometimes

Anonymous

-

-

Anonymous

cannabinoid rx

moderately effective in many conditions but AE's common

ARUP KUMAR DHARA

Impact assessment i7

Very good