Limited amount and quality of data on medications for treating neuropsychiatric symptoms of dementia

Clinical Question

Which medications are most effective in treating neuropsychiatric symptoms in adults with dementia?

Bottom line

A small number of studies, disappointing in overall quality, suggest that for managing neuropsychiatric symptoms in adults with dementia, risperidone has the best balance of effectiveness and adverse effects. 2a-

Study design: Meta-analysis (randomized controlled trials)

Funding: Foundation

Setting: Various (meta-analysis)

Reviewer

Henry C. Barry, MD, MS
Professor
Michigan State University
East Lansing, MI


Discuss this POEM


Comments

ARUP KUMAR DHARA

Impact assessment

Excellent

Kathleen Alayna Clarkson

What type of dementia that they have

As a geriatrician seeing and treating neuropsychiatric symptoms of dementia daily, one glaring omission stands out: what type(s) of dementia did these study participants have? The "bottom line" oversimplifies so suggest that antipsychotics would be first line. In fact they can be highly problematic in parkinsonian dementias including Lewy Body. Moreover, the first line treatment - and consistently the most powerful interventions - is non-pharmacologic.