Morning and bedtime dosing of antihypertensives have similar rates of major cardiovascular events (TIME)

Clinical Question

Does bedtime administration of blood pressure medications improve outcomes?

Bottom line

In contrast with the large Hygia Chronotherapy Trial, this equally large TIME study found that it didn’t matter when patients took their blood pressure medications. Since medications are ineffective while still in the bottle, patients should take their antihypertensive medication when it suits them best. 2b

Study design: Randomized controlled trial (single-blinded)

Funding: Government

Setting: Outpatient (any)

Reviewer

Henry C. Barry, MD, MS
Professor
Michigan State University
East Lansing, MI


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Comments

Anonymous

Antihypertensive dosing

Good to know they can be taken at night, possibly lowering side effects.

Anonymous

Quand prendre son anti-hypertenseur

L’information est utile mais je trouve curieux que les chercheurs n’ont pas reporté la qualité du contrôle de l’hypertension dans le sens de la moyenne des tensions artérielles plutôt que savoir si une personne a un infarctus ou pas

Anonymous

BP meds morning or bedtime dosing

'To believe, or not to believe, that is the question' .... 'ay, there's the rub' ..........

Anonymous

timing of meds

no difference

Anonymous

hs bp meds

no difference in am vs pm bp meds cvs complications

ARUP KUMAR DHARA

Assessment

Very good

Anonymous

Good

Good