Rivaroxaban is effective and safe for thromboprophylaxis after bariatric surgery

Clinical Question

Is rivaroxaban safe and effective for thromboprophylaxis in adults after bariatric surgery?

Bottom line

Rivaroxaban 10 mg orally once daily is effective and safe for thromboprophylaxis after bariatric surgery. This study found no difference in VTE events or clinically relevant bleeding events in patients who received therapy for 7 days versus 28 days. 1b

Study design: Randomized controlled trial (double-blinded)

Funding: Industry

Setting: Inpatient (any location) with outpatient follow-up

Reviewer

David C. Slawson, MD
Professor and Vice Chair of Family Medicine for Education and Scholarship
Atrium Health
Professor of Family Medicine, UNC Chapel Hill
Charlotte, NC


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Comments

Anonymous

Underpowered?

The event rate was so low in this study that it’s hard to gauge the relevance of these findings. In a low risk population, the risk was low regardless of the strategy.

ARUP KUMAR DHARA

Impact assessment

Excellent

Anonymous

dvt pr

xarelto ok

Anonymous

DVT prophylaxis after bariatric surgery

I see no comparison to a placebo group, or other DVT prophylaxis, and I am not sure what the recommendation is, 7 days or 28 days.