Postexposure prophylaxis with doxycycline in men who have sex with men and transgender women with or at risk of HIV reduces STI risk (NNT = 5)

Clinical Question

Does postexposure prophylaxis with doxycycline in men who have sex with men or transgender women who are either living with human immunodeficiency virus or using preexposure prophylaxis reduce the risk of sexually transmitted infection?

Bottom line

Men who have sex with men and transgender women who have or are at risk of HIV disease benefit from taking a single dose of doxycycline 200 mg following condomless sexual intercourse (NNT = 5). The patients studied were at high risk of STI based on a history of condomless anal or oral sex with a man and a diagnosis of gonorrhea, chlamydia, or early syphilis in the past 12 months. 1b-

Study design: Randomized controlled trial (nonblinded)

Funding: Government

Setting: Outpatient (any)

Reviewer

Mark H. Ebell, MD, MS
Professor
University of Georgia
Athens, GA


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Comments

Anonymous

Doxycycline post exposure

Plus added benefit of possibly preventing Lyme disease ! 😁

ARUP KUMAR DHARA

Impact assessment

Excellent