Herbal infusion seems effective in reducing risk of death from sepsis (EXIT-SEP)

Clinical Question

Does injection with Xuebijing decrease mortality in patients with sepsis?

Bottom line

This study showed that an herbal infusion, XBJ, is effective in decreasing short-term mortality in patients with sepsis, with no increase in adverse events compared with placebo. Several concerns remain about the study itself and the approval process for XBJ outside of China. However, the impressive NNT of 14 is noteworthy, making XBJ something to watch for in the future. 1b

Study design: Randomized controlled trial (double-blinded)

Funding: Government

Setting: Inpatient (any location) with outpatient follow-up

Reviewer

Nita Shrikant Kulkarni, MD
Assistant Professor in Hospital Medicine
Northwestern University
Chicago, IL


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Comments

Arup Kumar Dhara

Impact assessment

Very good

Anonymous

HERBAL INFUSION

GOO0D TO KNOW

Anonymous

No

No