Improved outcomes with azithromycin vs beta-lactams for acute exacerbations of chronic obstructive pulmonary disease

Clinical Question

Does azithromycin produce better results than beta-lactam antibiotics in patients hospitalized for acute exacerbations of chronic obstructive pulmonary disease?

Bottom line

In this retrospective analysis of hospital records of patients admitted for acute exacerbation of COPD, azithromycin was better at preventing a composite outcome of treatment failure, including readmission and the need for a change in antibiotic management, as compared with a beta-lactam. This study provides weak guidance but there is little other research evaluating the difference with these 2 classes of antibiotics. 2b

Study design: Cohort (retrospective)

Funding: Unknown/not stated

Setting: Inpatient (ward only)

Reviewer

Allen F. Shaughnessy, PharmD, MMedEd
Professor of Family Medicine
Tufts University
Boston, MA


Discuss this POEM


Comments

ARUP KUMAR DHARA

COPD

Very good

Anonymous

Azithromycin & COPD

See reviewers comments