mRNA vaccine in children aged 5 to 11 years is associated with fewer symptomatic COVID-19 infections and less multisystem inflammatory syndrome

Clinical Question

Are mRNA vaccines against COVID-19 effective and safe in children 5 to 11 years of age?

Bottom line

The existing data, mostly from observational studies, show that the 2-dose mRNA vaccine against COVID-19 is associated with fewer infections and hospitalizations and markedly fewer cases of multisystem inflammatory syndrome. Although nearly all children will have local reactions, approximately half will have systemic reactions and fewer than 10% will have disruption of their daily activities. 2a-

Study design: Meta-analysis (other)

Funding: Unknown/not stated

Setting: Various (meta-analysis)


Henry C. Barry, MD, MS
Michigan State University
East Lansing, MI

Discuss this POEM



Impact assessment


Randall Reid Hurst



John W. Alvarez de Lorenzana

Reduced effectiveness & “Funding unknown”

The potential harms and adverse effects of the vaccines can outweigh the benefits in this age group. Just watch any number of reviews done on reduced vaccine effectiveness in this population e.g., Vinay Prasad MD MPH,

I’m also wondering where the funding for the study is coming from - why does it say “funding unknown” ?