No difference in major vascular complications with different blood pressure strategies after noncardiac surgery (POISE-3)

Clinical Question

For patients undergoing noncardiac surgery, do blood pressure management strategies for hypotension avoidance or hypertension avoidance decrease the risk of major vascular complications?

Bottom line

This large, randomized trial showed no difference in outcomes when comparing 2 different blood pressure management strategies — hypotension avoidance and hypertension avoidance — in the perioperative period. Adherence to the strategies, however, was suboptimal. Additionally, there was no difference between the 2 groups in clinically important hypotension during the postoperative period, despite the different strategies. 1b

Study design: Randomized controlled trial (nonblinded)

Funding: Government

Setting: Inpatient (any location)

Reviewer

Nita Shrikant Kulkarni, MD
Assistant Professor in Hospital Medicine
Northwestern University
Chicago, IL


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Comments

ARUP KUMAR DHARA

Impact assessment

Excellent

Anonymous

Innovative

Inormative