Certain hormonal contraceptives increase thromboembolism risk when taken with NSAIDs

Clinical Question

Is the risk of venous thromboembolism increased when a nonsteroidal anti-inflammatory drug is taken with a hormonal contraceptive?

Bottom line

In this large study of women, NSAID use was associated with a small increase (0.004%) in the risk of VTE. Combining NSAID use with a medium-risk hormonal contraceptive increases the risk to 0.011%; the addition of a high-risk hormonal contraceptive increases the risk to 0.023%. 1b

Study design: Cohort (prospective)

Funding: Foundation

Setting: Population-based

Reviewer

Allen F. Shaughnessy, PharmD, MMedEd
Professor of Family Medicine
Tufts University
Boston, MA


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Comments

ARUP KUMAR DHARA

Impact assessment

Excellent

Anonymous

CERTAIN CONTRACEPTIVES INCREASE THROMBOEMBOLIC RISKS WITH

GOOD TO KNOW