Monthly vitamin D supplementation slightly decreases risks for cardiovascular events without increased adverse effects

Clinical Question

Can monthly vitamin D supplementation decrease the risk of experiencing a major cardiovascular event?

Bottom line

In this large study of more than 21,000 older participants (aged 60 to 84 years), taking 60,000 IU vitamin D each month slightly reduced their likelihood of experiencing a major cardiovascular event (number needed to treat = 172 over 5 years). The benefit is small but aligns with benefits seen with other preventive measures (and was additive to those already used by patients). Side effects were similar among the participants who took vitamin D and those who took placebo. The supplementation does not reduce the risk of mortality over 5 years. 1b

Study design: Randomized controlled trial (double-blinded)

Funding: Government

Setting: Outpatient (any)

Reviewer

Allen F. Shaughnessy, PharmD, MMedEd
Professor of Family Medicine
Tufts University
Boston, MA


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Comments

DR ARUP KUMAR DHARA

Impact assessment

Excellent

Anonymous

VITAMIN D AND CARDIOVASCULAR EFFECTS

GOOD TO KNOW

Anonymous

Vit D supplementation & CV events

Insufficient information. Factors such as specific vessels, degree of arterial blockage, coronary calcification etc would be relevant.

Anonymous

Another reason to take Vitamin D

The data just keep piling up for Vitamin D