One year of once-daily doxycycline does not reduce exacerbation frequency in adults with moderate to severe COPD

Clinical Question

Does 12 months of once-daily doxycycline prevent exacerbations in adults with moderate to severe chronic obstructive pulmonary disease?

Bottom line

In this adequately powered study, once-daily doxycycline for 1 year was no better than placebo at decreasing exacerbations in adults with moderate to severe COPD with at least one significant exacerbation in the previous year. Stay tuned for more robust studies in adults with severe COPD and in adults without eosinophilia. (LOE = 1b)

This POEM aligns with Choosing Wisely Canada's Using Antibiotics Wisely campaign recommendation : Don’t routinely prescribe antibiotics for exacerbations of Chronic Obstructive Pulmonary Disease unless there is clear increase in sputum purulence with either increase in sputum volume and/or increased dyspnea.

Study design: Randomized controlled trial (double-blinded)

Funding: Government

Setting: Outpatient (any)

Reviewer

Henry C. Barry, MD, MS
Professor
Michigan State University
East Lansing, MI


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Comments

Arup Kumar Dhara

Impact assessment

Excellent

Anonymous

learning antibiotic treatment may not be helpful for term pr

good information

Roland Michael Grad

Rating the last daily POEM

Sadly, our POEMs CME program is ending. Just want to say thanks to the CMA and their outstanding team of librarians for this CME opportunity.

Anonymous

DAILY DOXYCYCLINE DOES NOT REDUCE FREQUENCY ,EXACERBATIO

GOOD TO KNOW

Anonymous

copd and doxycycline use

useful information