Epicutaneous patch immunotherapy reduces severity of peanut allergy reactions and increases eliciting dose

Clinical Question

Is epicutaneous immunotherapy (patch-based therapy) safe and effective in reducing the severity of peanut allergy in children 1 to 3 years of age?

Bottom line

Epicutaneous therapy using a peanut patch reduced the severity of reactions and was more likely to increase the dose required to elicit a reaction. However, one-third of children responded without any intervention (natural history of the condition) and anaphylactic reactions were more common in the treated group. Most important, long-term follow-up of serious allergic reactions was not part of this study. 1b

Study design: Randomized controlled trial (double-blinded)

Funding: Industry

Setting: Outpatient (specialty)

Reviewer

Mark H. Ebell, MD, MS
Professor
University of Georgia
Athens, GA


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Comments

Arup Kumar Dhara

Impact assessment

Excellent

Anonymous

Peanut allergy

Industry sponsored, attempting to make a questionable therapy more marketable.

Anonymous

peanut allergy

patch

Anonymous

Hope for peanut allergic kids

Peanut allergy is likely over diagnosed and quite common now. Any therapy like this which can reduce peanut exposure reactions is welcome.

Anonymous

EPICUTANEOUS PATCH IMMUNOTHERAPY REDUCES SEVERITY OF PEANUT

GOOD TO KNOW