No aspirin = aspirin after 24 weeks’ gestation in some pregnancies at high risk for preeclampsia

Clinical Question

Is the discontinuation of aspirin beyond 24 to 28 weeks’ gestation noninferior to continuation among a subgroup at high risk for preeclampsia?

Bottom line

For pregnant individuals at high risk for preterm preeclampsia who were treated with aspirin starting late in the first trimester and with normal biomarker assessment for placental ischemia at 24 to 28 weeks’ gestation, the incidence of preterm preeclampsia did not differ if aspirin was stopped or continued. As expected, there were fewer bleeding complications in the discontinuation group. 1b

Study design: Randomized controlled trial (nonblinded)

Funding: Government

Setting: Outpatient (specialty)


Linda Speer, MD
Professor and Chair, Department of Family Medicine
University of Toledo
Toledo, OH

Discuss this POEM



Impact assessment

Very good


Aspirin use questionable to prevent pre-eclampsia

Good information


asa preeclamsia

asa consideration