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Clinical Question
Is the administration of the COVID-19 vaccine during pregnancy associated with preterm birth, small for gestational age at birth, or stillbirth?
Bottom line
Vaccination against COVID-19 during pregnancy is not associated with an increase in adverse pregnancy outcomes. Other research has also not found problems with vaccination during pregnancy. 1b
Reference
Study design: Cohort (retrospective)
Funding: Government
Setting: Population-based
Synopsis
This study used data from the provincial birth registry for the province of Ontario, Canada, between May 1 and December 31, 2021. These data are linked to vaccination database, allowing researchers to link birth outcomes to vaccination status. During this time, there were 85,162 births; 43,099 (50.6%) of them were related to individuals who received at least one vaccine (68.9% received 2 or more doses). Most vaccines were received during the second and third trimesters (87.9%) and were primarily the Pfizer–BioNTech BNT162b2 vaccine (80.1%) or other mRNA vaccines. Vaccination during pregnancy was not associated with any increased risk of overall preterm birth (6.5% vs 6.9%), spontaneous preterm birth (3.7% vs 4.4%), or very preterm birth (0.59% vs 0.89%). The risk of stillbirth and small for gestational age at birth was also not affected by vaccination. The investigators did not find any differences when analyzing by trimester of vaccination, type of vaccine, or number of doses received during pregnancy.
Reviewer
Allen F. Shaughnessy, PharmD, MMedEd
Professor of Family Medicine
Tufts University
Boston, MA
Comments
covid 19 immunization and pregnancy
no consequences
COVID 19 VACCINES DURING PREGNANCY
BENEFITS BUT NO ADVERSE EFFECTS ON PREGNANCY