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More melatonin and CBD in melatonin gummies than indicated by the product label
Question clinique
What is the actual quantity of melatonin and cannabidiol in over-the-counter melatonin gummies compared with the quantities declared on the labels?
L’Essentiel
Nearly 90% of melatonin gummy products analyzed in this study were inadequately labeled. The actual quantity of melatonin ranged from 74% to 347% of the labeled quantity. Similarly, the quantity of CBD ranged from 104% to 118% of the labeled quantity. Be sure to warn parents of the risk of excessive melatonin and CBD ingestion with the gummies. 2b
Référence
Plan de l'etude: Cohort (prospective)
Financement: Self-funded or unfunded
Cadre: Population-based
Sommaire
Although melatonin products are not approved by the US Food and Drug Administration, they are sold over the counter as dietary supplements. One product attractive for pediatric use are melatonin gummies, marketed to help improve sleep disturbances. These investigators identified 30 unique brands of products formulated as gummies with "melatonin" on the label. All were analyzed for their actual quantity of melatonin, cannabidiol (CBD), and serotonin. Compared with the quantity declared on the product label, most products exceeded the declared amounts of melatonin and CBD. One product contained no melatonin but contained a significant quantity of undeclared CBD. Overall, the quantity of melatonin ranged from 74% to 347% of the labeled quantity, with only 3 products (12%) containing a quantity of melatonin that was within 10% of the declared quantity. Similarly, the actual quantity of CBD ranged from 104% to 118% of the labeled quantity.
Reviewer
David C. Slawson, MD
Professor and Vice Chair of Family Medicine for Education and Scholarship
Atrium Health
Professor of Family Medicine, UNC Chapel Hill
Charlotte, NC
Commentaires
Impact assessment
Excellent
Practice changing
practice changing
OTC Melatonin supplements
Poor quality control in production. Caveat emptor.